The following year, he won each of his first World Series championships, MLB All-Star selection, and Gold Glove Award.

[21] Tucker spent the 2019 minor league season with the Round Rock Express, hitting .266/.350/.555/.905 with 34 home runs, 97 RBIs, and 30 stolen bases.

[24] He played in 13 playoff games, batting .306/.327/.367 before a season-ending loss to the Tampa Bay Rays in the American League Championship Series (ALCS).

He ranked ninth in the AL in batting, third in slugging percentage and OPS, fifth in doubles and OPS+, and tenth in Wins Above Replacement (5.7 WAR, per Baseball-Reference).

[24] He was named as a Gold Glove finalist in right field with +11 Defensive Runs Saved (DRS), tied with Joey Gallo and Aaron Judge for second place behind Adolis García.

[36] On April 27, his three-run double in the fifth inning versus the Texas Rangers scored the decisive runs for a 4–3 Astros win; he collected seven RBIs in the first three games of that series.

[41] Tucker was named a reserve outfielder to the MLB All-Star Game at Dodger Stadium, his first career selection.

Some totals at the time included a .259 average, 16 home runs, fourth place ranking in the AL in RBIs (58) and tied for fifth in steals (14).

[45] A double in the third inning versus the Minnesota Twins on August 24 extended a hitting streak to a new career-high 16 games for Tucker.

[48] On September 20, Tucker, facing his hometown Rays, drove in his 100th run of the season to become the 18th player in club history to accomplish the feat, and first full-time Astros outfielder since Carlos Lee in 2009.

[49] The following day, Tucker hit the go-ahead home run the eighth inning that resulted in a 5–2 win, finishing off a series sweep at Tropicana Field, the first ever for Houston in Tampa Bay.

[62] Tucker was announced on September 11 as the Astros' nominee for the 2024 Roberto Clemente Award, whose foundation assists those in hospice care and children with cancer diagnoses.

[63] From September 20–21, 2024, Tucker produced consecutive four-hit games, making him the 14th Astro to accomplish the feat, and first since former teammate Michael Brantley on July 5–7, 2019.

His slash line and OPS+ (181) both represented career bests though he did not accrue enough plate appearances to quality for the batting title (339).

[24] On December 13, 2024, Tucker was traded to the Chicago Cubs in exchange for Isaac Paredes, Hayden Wesneski, and prospect Cam Smith.

[66] Tucker's older brother, Preston, is also a professional baseball outfielder who was drafted by, and played for, the Astros, appearing with the major league club in 2015 and 2016.

Preston held the Plant High School home run record with 29 until Kyle surpassed his and finished with 31.

They both graduated from Plant High School in 2015 and began dating in 2017 while Scott was attending Florida State University.

In early 2022, Tucker initiated his eponymous foundation to increase awareness for non-profit hospice care centers.