Kynurenine—oxoglutarate transaminase

In enzymology, a kynurenine-oxoglutarate transaminase (EC 2.6.1.7) is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are L-kynurenine and 2-oxoglutarate, whereas its two products are 4-(2-aminophenyl)-2,4-dioxobutanoate and L-glutamate.

[1] This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups.

The systematic name of this enzyme class is L-kynurenine:2-oxoglutarate aminotransferase.

KYAT1, AADAT (aka KYAT2), and KYAT3 are examples of enzymes of this class.

[2] As of early 2009, 18 structures have been solved for this class of enzymes, with PDB accession codes 1X0M, 1YIY, 1YIZ, 1W7L, 1W7M, 1W7N, 3E2F, 3E2Y, 3E2Z, 2ZJG, 2YGZ, 2Z61, 2R5C, 2R2N, 2R5E, 3B46, 3DC1, and 2QLN.