Kyra Jefferson (born September 23, 1994) is an American professional sprinter.

She competed for the University of Florida through 2017 before receiving a Nike sponsorship.

She won a silver medal at the 2015 Pan American Games in the 200m and a gold in the 4 × 400 m relay.

At the 2017 NCAA Division I Women's Outdoor Track and Field Championships, she defeated pre-race favorite and Olympian Deajah Stevens of Oregon to break the American collegiate record in the 200m with a time of 22.02 seconds.

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