Kyrion II was born as Giorgi Sadzaglishvili (გიორგი საძაგლიშვილი) in the village of Nikozi, Georgia (then part of the Tiflis Governorate, Imperial Russia), into the family of a priest.
Returning to Georgia in 1883, he served both as a teacher at the theological schools in Gori, Kutaisi and Tbilisi, and a church official.
After the death of his wife and children, he became a monk, assumed the name of Kyrion, and was ordained to the position of archimandrite at Kvatakhevi Monastery in 1896.
For this reason, he was removed from Georgia to Kamenets-Podolsk (now Kamianets-Podilskyi, Ukraine) (1902) and later to Kovno (now Kaunas, Lithuania) (1903).
[3] Kyrion was deprived of the title of bishop, sent to Kuriazh, Ukraine, and later confined into the Sanaksar Monastery in Mordovia.