In 1855 Heuzey went to Greece as a member of the École française d'Athènes, and for the next two years traveled extensively in Macedonia and Akarnania.

The record he kept of his journey, "Le Mont Olympe et l'Acarnanie", was published in Paris in 1860.

He began excavations there in 1861, later extending his archaeological ventures to Philippi, western Macedonia, Illyria and Thessaly.

[2] In 1893 he discovered the site of Delphi,[citation needed] which led to its excavation and appreciation of its significance.

He was also an expert on historic costumes of the Ancient Greek, Byzantine, Egyptian and Roman eras and author of Histoire du costume antique d'après des études sur le modèle vivant.