The Lötschental was likely first settled during the Roman period, but remained largely cut off from the outside world until the beginning of the twentieth century.
The valley remained remote and difficult to access, especially during the winters, until the construction of the Lötschbergbahn, between 1907 and 1913, connected it to an international railway line.
Traditional farming, involving primarily agriculture and cattle and sheep rearing, began to disappear with the extension of the road to Blatten after World War II.
The Lötschental is now a destination resort for hiking with many tracks, such as the Höhenweg, and winter sports, including Nordic and Alpine skiing as well as sledging and snowshoeing.
The Lötschental is known for its unique local custom involving the so-called Tschäggättä: frightening figures wearing furs and carved wooden masks that walk the streets during carnival tossing soot at onlookers.