In 2004, she began her profession career by releasing her first album Giấc mơ có thật, which gained much success after 6 years singing in Ha Noi and Ho Chi Minh City.

[1][2][3] In the late 2000s, she released a series of musical projects that were commercially and critically successful, including albums Lời Yêu Còn Mãi (2006), Lệ Quyên Acoustic (2009), Nếu Như Ngày Đó (2009).

[4] In 7th grade, her family faced crisis so she and her mother moved to Thai Nguyen of where she enrolled at secondary and highschool Luong Ngoc Quyen.

[4] Also in 2004, she was starred as singer Minh Thuy in 8 episode TV drama Bản Lĩnh Người Đẹp (directed by Nguyễn Anh Tuấn).

[13][14] After Bản Lĩnh Người Đẹp, she was invited to portray leading role of 28 episode TV drama but she denied as she would like to focus on music instead.

[18] Despite first album, she already produced many hits: Giấc Mơ Có Thật, Hãy Trả Lời Em, Thôi Đừng Chiêm Bao, Quên Một Cuộc Tình, Phút Giây Hạnh Phúc,...Especially, she was the last singer that enabled to sing foreign songs without having to ask for copyright permission.

In 2005, she collaborated in many albums like Phố Cũ Của Tôi (Tình Khúc Phú Quang) and the song Lãng Đãng Chiều Thu Hà Nội, in Lê Hiếu's Vol.

On June 16, 2005, she released a duet album featuring Hoàng Thiên Long named Lời Ăn Năn Muộn Màng - Trái Tim Buồn.

On November 2, 2008, after many "promises", the golden duo Lệ Quyên and Tuấn Hưng released a duet album named Như Giấc Chiêm Bao as a gift to music lovers and it made quite good first impression.

[37] On August 27, 2010, she held a press conference to introduce her special album Khúc Tình Xưa as a collection of famous songs of the past.

[38][39][40] The album included 12 songs such as Mưa Nửa Đêm, Tình Lỡ, Hàn Mạc Tử, Sầu Lẻ Bóng,...which was edited by herself.

A lot of famous singers were invited such as: Dam Vinh Hung, My Dung, Ho Ngoc Ha, Tuan Hung, Le Hieu, Minh Quan, Vu Thu Phuong...Her spouse is the nephew of songwriter Le Quang as well as the owner of Không Tên music tea room[52]-one of the most famous tea room in Ho Chi Minh City.

4 – Để Nhớ Một Thời Ta Đã Yêu which included 9 songs from: Thai Thinh, Tuong Van, Vinh Tam, A.

[56][57][58] On December 10, 2011, she released the next album of the project Khúc Tình Xưa titled Trả Lại Thời Gian including 11 immortal love songs: Trả Lại Thời Gian, Ai Khổ Vì Ai, Sang Ngang, Mưa Rừng, Nửa Đêm Ngoài Phố,...[59][60][61] Especially, the album firstly marked her first time collaboration with singer Quang Le for the song Sầu Tím Thiệp Hồng.

[68] The liveshow had the appearance of A-list singers: Thu Minh, Hien Thuc, Uyen Linh, Ho Ngoc Ha and special attendance of actor Huu Chau.

[69][70][71] On August 27, 2012, VLT Lawyers sent official statement to 9 websites which had violated copyright law to proceed 15,3 billion Vietnam dong payment for Lệ Quyên and Viet Tan Production as the deadline was September 15, 2012; as well as asking to stop using her songs illegally.

[97][98][99][100] In December 7 and 14 2013, at Hoa Binh Theater and National Conference Center Ha Noi was still crowded as she launched Q Show with the attendance of more than 7,500 audiences and performed 42 songs from pop, ballad, bolero, pre-war and contemporary.

[109] After the release, she brought Q Show to other audiences from 10 different countries in Europe, and 30 states of America, as well as Sydney and Melbourne in Australia in May, June, July, September and November.

Besides, she also shared that she had spent lots of time discussing with the legal copyright owner in order to record all the songs correctly following Vu Thanh An's request.

Vu Thanh An himself carefully corrected each note, each lyric before handing Le Quyen the final pieces so she could perform live nationally.

The album included 11 old songs which had been carefully edited by herself such as: Đêm Tâm Sự, Sương Lạnh Chiều Đông, Chuyến Tàu Hoàng Hôn, Kiếp Cầm Ca,....was bolero masterpieces, Lệ Quyên once again seeded the audience with as sweet as honey audios.

On July 23, 2015, the press conference for the launch of liveshow Vũ Thành An & Lệ Quyên - Tình Khúc Không Tên produced by Phuong Nam Film and Le Quyen who was the main vocal that was held at Gem Center.

Tình Khúc Không Tên was the first liveshow in Vietnam that presenting one kind of music from Vu Thanh An, the ticket was sold out quickly after nearly 2 weeks.

Also in the official launch of the liveshow, music booklet Tình Khúc Vũ Thành An was introduced for the very first time which consisted of 39 songs from the songwriter.

[139][140] Hoa Binh Theater was filled with more 2.500 audiences proved that Le Quyen was one of a few singers that could be able to successfully perform Vu Thanh An's songs.

[167] Đoạn Tuyệt was the one that Thai Thinh had specially written for Lệ Quyên under the influence of bolero, since many liked it so she bought the unlimited copyright in Vietnam and oversea.

[170][171][172][173][174] On February 22, 2017, she was confirmed to be one of the coaches for the reality show Bolero Idol second season alongside three famous ballad singers Ngoc Son, Dam Vinh Hung and Quang Le.

On January 15, 2018, after 20 years of conduction, she finally released the album Lệ Quyên & Trịnh Công Sơn which consisted of 12 masterpieces from the excellent songwriter such as: Ướt Mi, Diễm Xưa, Ru Em Từng Ngón Xuân Nồng, Ru Ta Ngậm Ngùi, Biển Nhớ,....[193][194][195][196] On the first day, 4,000 copies was sold out although there hadn't been any official statement regarding the album release previously.

Starting from the sympathy and wanting to support artists who live under difficult conditions, she and other colleagues like Dam Vinh Hung, Quang Linh,...has been using their voice to raise the fund.

She has unique personality and own color in music, it's why I often get nervous whenever having a duet with her", February 18, 2017 - Bằng Kiều"Le Quyen is a senior whom I really admire as well as being an idol that I would like to achieve in my career.