[1][3][4] The row of buildings located at 1810–1820 19th Street NW was designed by local architectural firm Wood, Donn, & Deming in 1904 and built by John N. Nolan.

[1][8] Notable owners of the home during the early 20th century included United States Senators James K. Jones[9] and Claude A.

[12][13] Additional Scientology organizations once located at the L. Ron Hubbard House include the National Academy of American Psychology (NAAP).

[1] In January 1963, the U.S. Food and Drug Administration (FDA) ordered a raid against the Academy's 19th Street location, seizing more than 100 e-meters (electronic devices used by Scientologists) and 200 pieces of literature.

[1][5] In 2022 the property owners filed a historic landmark nomination for the building due to its connection with Hubbard and the Founding Church of Scientology.

[3][4] The three-story L. Ron Hubbard House is an example of eclectic Beaux-Arts architecture with Mediterranean, Italiante, Georgian Revival, and Neoclassical details.

[5][20] The museum describes itself as "the landmark location of the first Church of Scientology where writer, explorer and founder L. Ron Hubbard worked from 1957 to 1960 and established a legacy that increasingly influences human rights, religion, literature and education.

[1] They are decorated with 1950s era furniture and include a briefcase and globe once owned by Hubbard as well as an outfit he once wore displayed in a glass case.

The top floor includes photographs of celebrities associated with Scientology and the group's headquarters in Clearwater, Florida, and a sign with Hubbard's quote "A Scientologist is one who controls, persons environments and situations."

Since October 27, 2003, ownership of the building has been registered to Heritage Properties International,[19] a subsidiary of Scientology's Church of Spiritual Technology.