Subramaniam developed a passion for music as well as science from a young age, studying Medicine and acquiring his M.B.B.S.

[4] Since 1973, Subramaniam has amassed over 200 recordings to his credit, releasing several solo albums, recording collaborations with musicians Yehudi Menuhin, Stéphane Grappelli, Ruggiero Ricci and Jean-Pierre Rampal, further to making albums and performing with Ruggiero Ricci, Herbie Hancock, Joe Sample, Jean-Luc Ponty, Stanley Clarke John Handy, George Harrison[7] and several others.

[8][9] In 1983, he composed a Double Concerto for violin and flute which combined western scales with micro intervals.

The release of his albums, including Global Fusion in 1999 have brought Subramaniam widespread critical acclaim, and popularity for his advanced playing.

In 2004, he completed a world tour with the festival, including concerts in the US (Lincoln Center, New York), the Asian Pacific region including in Perth, Australia, at the Esplanade, Singapore, the Sri Dewan Penang Hall in Penang and the Putra World Trade Centre in Kuala Lumpur, Malaysia.

Performing with Subramaniam at the festival in January 2005 were violin maestro Arve Tellefsen, the Oslo Camerata, jazz legends Stanley Clarke, George Duke, Al Jarreau, Earl Klugh and Ravi Coltrane.

Subramaniam is on the advisory board of composer A. R. Rahman's KM Music Conservatory in Kodambakkam, Chennai.

On 24 October 2012, he performed as a Special Guest Artist with Stevie Wonder at the latter's message of peace concert at the UN.

[10] Subsequently, on January 11, 1992, Vijayashree and Subramaniam launched the Lakshminarayana Global Music Festival (LGMF) in Madras (Chennai).

[11] Artists have included the Subramaniam family, Al Jarreau, George Duke, Solo Cissokho, Miya Masaoka, Mark O'Connor, Loyko, Jean-Luc Ponty, Ustad Bismillah Khan, Larry Coryell, Arve Tellefsen, Pandit Jasraj, Dr. M. Balamuralikrishna and Corky Siegel.