On 18 November 2022, the Airbus A320neo was taking off from Jorge Chávez International Airport when it collided with a fire engine that was crossing the runway, killing two firefighters and injuring a third, who died of his injuries seven months later.

[4] The weather at Jorge Chávez Airport at the time reported a 10-knot (19 km/h; 12 mph) southerly wind, visibility of at least 10 km (5.4 nmi; 6.2 mi), and a broken cloud layer at 2,100 ft (640 m).

During the take-off roll, multiple airport crash tenders and fire engines on a planned emergency drill crossed the runway in front of the accelerating aircraft.

[5] The pilots of the aircraft were arrested soon after the accident and held in custody for 24 hours, prompting the International Federation of Air Line Pilots' Associations (IFALPA) to criticize the Peruvian government for acting contrary to International Civil Aviation Organization guidelines, saying that the arrest and detention were "extremely detrimental to flight safety and can only hinder the investigation."

IFALPA also said that the arrest could create the public impression that the accident was intentionally caused by the pilots rather than by "technical issues or a string of errors originating from multiple factors.

Firefighter Manuel Villanueva, the only survivor of the three-man fire engine crew, succumbed to his injuries on 17 June 2023, making him the third fatality of the accident.

[9]: 10 On October 2, 2023,[5] the CIAA released their final report, which concluded that the crash had been the result of the emergency vehicles entering the runway without permission.