[2] In 1983, LGBT Humanists lobbied Amnesty International to begin providing support for gays and lesbians in countries where people were persecuted for their sexuality.

[2] In 1989, Anthony Grey from the Homosexual Law Reform Society congratulated LGBT Humanists on its 10th anniversary, saying "Constantly having to combat irrational and dangerous thinking is strenuous and sometimes tedious, but not necessarily boring.

[2] From its inception, the Gay Humanist Group worked to combat widespread prejudice and religious bigotry towards LGBT people in the UK, at a time when attitudes to homosexuality were still fairly negative on the whole.

[3] Two significant milestones came in 1987, when in partnership with Channel 4, the group organised a "live gay wedding" on terrestrial television, which in turn was the first same-sex kiss between men ever shown on British television, and later when the Hippodrome nightclub in London hosted a high-profile event where the group conducted 22 simultaneous gay weddings.

[3] Another came in 1999 when 11 couples, including the activist Barbara Smoker, were married on-screen for the BBC Two show Gaytime TV.

In 2019, following the successful passage of a bill to extend marriage equality, humanists paid for billboards across Belfast announcing "Love wins for everyone".

[8] In 2023, to mark 10 years since the passage of the Same-Sex Marriage Act, LGBT Humanists members David Cabreza and Peter McGraith, who had been the first same-sex couple to marry in England in 2014, delivered hundreds of postcards "cordially inviting" the Justice Secretary to recognise humanist marriages in England and Wales.

The act of organising a remembrance ceremony focused on LGBT people was publicly condemned as "distasteful" and "offensive" by the Royal British Legion at the time; the event was organised after the RBL privately refused to include LGBT veterans in the ceremony and had called the request "disgusting".

Despite strong opposition at first, Tatchell reported that LGBT contingents were eventually allowed to march as part of the official ceremony.

[15] Humanists again brought the issue to media attention[16] and to the UN Human Rights Council in 2018,[17] precipitating Theresa May's government to announce a ban on the practice.

LGBT Humanists works closely with organisations including Stonewall and Faith to Faithless to campaign against so-called 'conversion' therapy and to support and empower survivors of this discredited and harmful practice.