Lesbian, gay, bisexual, and transgender (LGBTQ) people in Ghana face severe challenges not experienced by non-LGBTQ residents.

The couple would observe all the social equivalents of heterosexual marriage, a bride price was paid and a traditional wedding ceremony was held.

[28] In a 2013 story published by MyJoyOnline, a local lawyer, John Ndebugri, argued against the common interpretation of Section 104 as prohibiting sex acts by same-sex participants.

[32] Section 12(2) of Chapter 5 of the Constitution of Ghana provides that, "Every person in Ghana, whatever his race, place of origin, political opinion, colour, religion, creed or gender shall be entitled to the fundamental human rights and freedoms of the individual contained in this Chapter but subject to respect for the rights and freedoms of others and for the public interest.

Later that same year, lawmakers proposed a bill containing extreme measures including prohibitions on any expression of non-binary gender or non-heterosexual identity.

Human Rights Watch reported an increase in anti-LGBTQ rhetoric associated with the publicity surrounding the proposed laws, in a "climate in which discrimination and violence is already rife".

Pearl, a 30-year old lesbian woman from Ghana, shares that Ghanaians take action into their own hands when dealing with the LGBTQ community.

A 10-person vigilante group had been monitoring a man, Ebenezer Okang, and one night visited his home to beat him, with the intentions of burning him alive.

[42] When asked if he had reported the event, Okang shared that it is difficult to seek protection in such situations, given Ghana's anti-LGBTQ laws and the police attitudes.

[42] According to Human Rights Watch, discrimination towards LGBTQ individuals is common in public and private, making it difficult for them to seek help.

[42][8] In a rare incident in April 2017, police in Accra arrested two men who had blackmailed, extorted and abused a gay man, and who had threatened to post nude pictures of him.

Reports emerged in August 2018 of conversion therapy programmers run by religious leaders to "cure" LGBTQ people of their homosexuality.

[9] There is no reliable evidence that sexual orientation can be changed, and medical bodies warn that conversion therapy practices are ineffective and potentially harmful.

The U.S. Department of State's 2011 Human Rights Report found that,[47] LGBT persons face widespread discrimination [in 2010], as well as police harassment and extortion attempts.

In June 2010 ... more than 1,000 protesters in Takoradi, Western Region, participated in a peaceful rally against reports of gay and lesbian activities in their city.

In a June 2010 interview with The Daily Graphic, the Western Region minister called on the government to take steps to combat homosexuality.

He included the possibility of police raids on locales frequented by gay men and lesbians, efforts by community leaders to "wean young people" away from homosexuality, and a public condemnation by the government.

The case was first brought to the Takoradi Circuit Court on 24 August; however, it had not been heard by year's end.The U.S. Department of State's 2012 Human Rights Report found that,[48] LGBT persons faced widespread discrimination, as well as police harassment and extortion attempts.

In March a gang of men assaulted nine people they believed to be LGBT individuals in Jamestown, a neighborhood of Accra, forcing them from their homes and attacking them with canes and sticks.

The assault occurred after they discovered he was carrying safe-sex presentation materials such as condoms, wooden sex organ replicas, lubricant, and pamphlets.

[54] In February 2017, the Speaker of the Parliament, Aaron Mike Oquaye called for amending the laws of Ghana to ban homosexuality entirely.

[19] The 2018 Human Rights Watch report noted that these types of comments made by government and public officials embolden homophobic acts of violence and discrimination towards the LGBTQ community.

In recent years, there have been several grassroot LGBTQ groups which have come together to form a bigger movement under the name Coalition Against Homophobia, Transphobia and Biphobia in Ghana.

[62] Despite Ghana having a low infection rate, the government's public campaign efforts on this health crisis typically present it as an issue for straight individuals.

[63] The office was raided and closed by National Security in late February 2021 due to opposition from locals, religions institutions, and politicians.

[12] Minister of Information and National Origin Kwamena Bartels said, "The government does not condone any such activity which violently offends the culture, morality ... and heritage of the entire people of Ghana.

In October 2019, the World Congress of Families, a US-based anti-LGBTQ group, held a conference in Accra,[68] during which they encouraged Africans to adopt the practice of conversion therapy.

However, police shut down the center after there had been many public protests, and pressure from religious groups, parties, and traditional leaders mainly in the Christianity faith.

[73] The memorandum of the bill claims that Ghana, its government, the majority of its citizens, its culture, and history completely disapprove of the LGBTQ community.

"[77] In March 2023, Ghana's President Nana Akufo-Addo announced that "substantial elements" of the Anti-LGBTQ+ bill being considered by parliament "have been modified" following an intervention by the government.