Lesbian, gay, bisexual, transgender, and queer (LGBTQ) people in the U.S. state of South Carolina may face some legal challenges not experienced by non-LGBTQ residents.

Same-sex sexual activity is legal in South Carolina as a result of the U.S. Supreme Court decision in Lawrence v. Texas, although the state legislature has not repealed its sodomy laws.

[2] South Carolina's sodomy laws, which made "buggery" a felony punishable by five years in prison or a $500 fine, were invalidated by the 2003 U.S. Supreme Court decision in Lawrence v.

[3] South Carolina voters adopted a constitutional amendment in November 2006 defining marriage as the union of a man and a woman and prohibited the recognition of same-sex relationships under any other name.

A married same-sex couple filed a lawsuit, alleging a violation of their Due Process and Equal Protection rights under the 14th Amendment as interpreted in Obergefell v. Hodges, after the state refused to list the non-biological mother on their twins' birth certificates.

U.S. District Judge Mary Geiger Lewis ruled that "listing a birth mother's spouse as her child’s second parent is one of the terms and conditions of civil marriage in South Carolina.

[13] Mount Pleasant,[14][15] Myrtle Beach,[16] and Richland County[17] prohibit discrimination on the basis of sexual orientation and gender identity in employment.

[29][30][31] A 2017 Public Religion Research Institute (PRRI) opinion poll found that 53% of South Carolina residents supported same-sex marriage, while 37% opposed it and 10% were unsure.