The LGV Méditerranée (French: Ligne à Grande Vitesse; English: Mediterranean high-speed line) is a 250-kilometre-long (160-mile) French high-speed rail line running from north to south between Saint-Marcel-lès-Valence, Drôme and Marseille, Bouches-du-Rhône, also featuring a connection to Nîmes, Gard to the west.

Construction costs rose to €3.8 billion; the line entered service in 2001 following an official opening by President Jacques Chirac.

LGVs Méditerranée, Rhône-Alpes and Sud-Est, when completed, also received their official nickname, the City To Coast (C2C) Highway ("Ville à la Mer").

After crossing the Canal de Donzère-Mondragon, the line connects to the regular network by an emergency link situated between Pierrelatte and Lapalud.

Spanning the Rhône three times (twice at Mornas, once north of Roquemaure), the LGV continues to Les Angles, where a triangle allows access to the southwest and southeast.