The LGV Rhône-Alpes (French: Ligne à Grande Vitesse; English: high-speed line) is a 115 km (71 mi) French high-speed rail line situated in the Auvergne-Rhône-Alpes region which extends the LGV Sud-Est southwards.

LGVs Rhône-Alpes, Sud-Est and Méditerranée, when completed, received their official nickname, the City To Coast (C2C) Highway ("Ville à la Mer").

The line crosses four departments from north to south: Ain, Rhône, Isère and Drôme.

The line comprises one new station: Gare de Lyon Saint-Exupéry, situated in the commune of Colombier-Saugnieu.

This station, with its striking architecture, is the work of the Spanish architect Santiago Calatrava.