34773074342ENSG00000162951ENSMUSG00000060780Q86UE6Q8K377NM_178839NM_028880NM_001362109NP_849161NP_083156NP_001349038LRRTM1 is a brain-expressed imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in neurons.

It is expressed during the development of specific forebrain structures and shows a variable pattern of maternal downregulation (genomic imprinting).

[9] Possessing one particular variant of the LRRTM1 gene slightly raises the risk of psychotic mental illnesses such as schizophrenia, again only if inherited from the father's side.

LRRTM1 is also critically involved in synapse formation within the dorsal lateral geniculate nucleus (dLGN) of mice.

Lack of this gene shows decreased performance in complex visual tasks.