A retelling of Dante's Divine Comedy, the multi-language libretto was constructed by Andriessen using extracts from Dante's poem as well as several other sources including the Old Testament and the poetry of Joost van den Vondel.

La Commedia premiered on 12 June 2008 at the Koninklijk Theater Carré in Amsterdam.

It received a further concert performance in London at the Barbican in 2016 performed by the BBC Symphony Orchestra with Cristina Zavalloni and Claron McFadden reprising their original roles as Dante and Beatrice.

[2][3][4] The opera won the 2011 Grawemeyer Award for Music Composition, and in 2014 the recording of the premiere production was released on CD and DVD.

[5][6] Ivan Hewett of The Telegraph wrote, “Like all Andriessen’s best pieces, this showed a man constantly engaged, in the most passionate terms, with the unfathomable dichotomies of human life; passion versus rationality, matter versus spirit, life and death.”[4] Andrew Clements of The Guardian rated the Dutch National Opera set four out of five stars and argued, “The tone is wonderfully varied – sometimes profoundly serious, sometimes wildly exuberant or irreverent – matched to a score that is equally diverse and eclectic.”[6] In the Los Angeles Times, Mark Swed lauded it as a “profoundly moving, if slyly unsentimental, meditation on life, love and death [...] it is Andriessen’s “Italian” opera and has the depth, musical richness and (I predict) lasting power of late Verdi.” Swed praised “the humor, the ingratiating jazziness, the terrible fury and, in the end, the ravishing grace of the later scenes.“[1] In a 2019 poll of critics and editors of The Guardian, the opera was ranked the seventh greatest classical composition of the 21st century, with Clements referring to the score as “wonderfully polyglot”.