[3] The main local editions are for Toulouse, Ariège, Aude, Aveyron, Haute-Garonne, Gers, Lot, Lot-et-Garonne, Hautes-Pyrénées, Tarn and Tarn-et-Garonne.

The newspaper first appeared on 2 October 1870 when it was called La Dépêche de Toulouse.

[4][5] Publication was prompted by workers at the Sirven print works in Toulouse, which established the paper's left-leaning politics.

Like other newspapers that had collaborated during the war, La Dépêche de Toulouse was closed by the postwar government in 1944.

[6] The combined circulation for the 17 regional dailies under La Dépêche du Midi was 200,000 copies in 2006.