La Folie du docteur Tube is a 1915 short silent experimental film directed by Abel Gance, in which a scientist takes a white, cocaine-like powder which makes him hallucinate.
He then sprays some powder on two lovely young girls who visit him, who are devastated by the result, as well as their fiancés who receive the same treatment.
The four young people come to blows with the professor, who then tells them that all they need to do is get rid of the dust that covers their clothes to regain a normal shape.
Abel Gance, about The Madness of Doctor Tube: "[...] I got drunk too quickly and said: 'I'm going to impress them all at the cinema because I have a very powerful idea.'
I used distorting mirrors, I did everything that I technically imagined the audience would appreciate immensely because it had never been done, and when I showed this film to the director and the people who interested in me, they said to themselves: 'He's crazy, we mustn't entrust him with a penny anymore, he's going to ruin us.