The bill was introduced into the U.S. Senate by Robert M. La Follette Jr. of Wisconsin and supported in the House by Alfred L. Bulwinkle of North Carolina.

The Title 42 Section 25 codified law was penned as five sections establishing federal rulings for the Public Health Service enforcement to control and eradicate venereal diseases in the United States as determined by the Surgeon General of the United States.

[1] The 79th United States Congress passed the Federal Food, Drug, and Cosmetic Act Penicillin Amendment on July 6, 1945.

The 1960s sexual revolution movement prompt the United States Congress to draft amendments for the Public Health Service Act authorizing control, prevention, and vaccination assistance for communicable diseases.

By 1914, American exploitation films were produced promoting awareness about hygiene and venereal disease.