La Grand-Croix (French pronunciation: [la ɡʁɑ̃ kʁwa]) is a commune and the seat of a canton in the Loire department in central France.

The commune was the main town of the former canton of La Grand-Croix, arrondissement of Saint-Étienne.

The commune is close to the Parc Naturel Régional du Pilat.

[4] The river Dorlay, a tributary of the Gier that rises in Mont Pilat, forms the border between La Grand-Croix and Lorette.

[5] Gustave Malécot (28 December 1911 – 1998), mathematician La Grand-Croix is twinned with: