The Spanish historic name for La Honda Creek was Arroyo Hondo, meaning "deep stream".

The La Honda Creek watershed drains 12.3 square miles (32 km2).

California State Route 84 (CA 84) follows the valley of the creek from Sky Londa to San Gregorio.

[6] The La Honda Creek watershed has been documented as historically supporting a salmonid population, including steelhead trout (Oncorhynchus mykiss) and potentially coho salmon (Oncorhynchus kisutch), however sediment eroding into the creek coupled with natural logjams present barriers to fish passage.

A 1985 California Department of Fish and Wildlife survey reported steelhead up to 2 miles (3.2 km) upstream of Weeks Creek, the highest named tributary, and reported that La Honda Creek provides good spawning and rearing habitat for steelhead downstream of Woodruff Creek, and resident rainbow trout (the landlocked form of steelhead trout) upstream of Woodruff Creek.