[1] Its first references were Jazz manouche, Klezmer, Balkan and Gypsy music, rhythms to which later they would incorporate Latin influences like Cumbia, Mambo, Cha-cha-cha, Tango and Rumba; creating a cosmopolitan sonority.

In 2008, the famous Serbian filmmaker Emir Kusturica and his No Smoking Orchestra asked La Mano Ajena to join them on stage during their show in Santiago, on October 13.

In February 2009, La Mano Ajena was invited once again to share stage with The No Smoking Orchestra during their 10th anniversary tour, in which they played in Viña del Mar, Chile.

About the Chilean musicians, Kusturica said to local press that there's a “special connection” between both bands,[5] while Nelle Karajlic, the singer and leader of the Serbian group, stated that in Serbia La Mano Ajena members were “heroes”.

In November 2009, La Mano Ajena opened the concert of the world famous New York gypsy punk band Gogol Bordello, on their first visit to Chile.