La Mesilla is a census-designated place in Río Arriba County, New Mexico, United States.

[4] In 1870, a family from La Mesilla was ambushed and killed by Mexicans disguised as Native Americans.

[5] According to the United States Census Bureau, La Mesilla has a total area of 17.67 square kilometers, of which 17.57 km2 is land and (0.82%) 0.1 km2 is water.

Of the 1772 inhabitants, La Mesilla was composed by 68.34% White, 0.34% were African American, 1.35% were Native American, 0.4% were Asian, 0% were Pacific Islanders, the 25.62% were of other races and 3.95% from two or more races.

Of the total population 73.36% were Hispanic or Latino of any race[8] It is in Española Public Schools.