La Mulatière (French pronunciation: [la mylatjɛʁ]; Arpitan: La Mulatiére) is a commune in the Metropolis of Lyon in the Auvergne-Rhône-Alpes region, central-eastern France.

It is located just southwest of Lyon,[a] on the right bank of the Saône; it is the final commune until its confluence with the Rhône at the southern end of Lyon's Presqu'île.

The town is known, among other things, for its Aquarium du Grand Lyon.

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