Shortly after its creation a community group Organization for the Protection of National Park La Muralla (OPMA) was created, but has since stopped functioning for lack of financial support.

Other players involved in the protection and maintenance of the park include: The first studies of biodiversity in La Muralla were conducted by the Forestry Conservation Project of Honduras (CONSEFORH) in 1992.

A total of 101 plants were identified, including melastome families, Lauraceae, Pasiflorácea and Solanaceae.

In 2001, the Paseo Pantera project cataloged 859 species of plants, including the previously recorded 101, corresponding to 410 genera and 127 botanical families.

In 2010, Dr. Dora Elisa Perez conducted a study with the discovery of 53 new varieties cataloged.