La Perle is a residential neighbourhood in west Edmonton, Alberta, Canada.

The neighbourhood is named for a resident (EJ LaPerle) who operated a general store in the area in the early.

West Edmonton Mall is located to the south east of La Perle in the neighbourhood of Summerlea.

The Anthony Henday provides access to destinations to the south of the city including the Edmonton International Airport.

Access to the downtown core and MacEwan University is provided by 100 Avenue which passes through the neighbourhood.