The weekend Saturday printed edition was discontinued on 31 December 2017, turning La Presse into an entirely online newspaper.

La Presse comprises several sections, dealing individually with arts, sports, business and economy and other themes.

It also organized a charity to give Christmas gifts to poor children (L'Oeuvre des étrennes aux enfants pauvres).

A front-page illustration on December 3, 1904, issue celebrated the 50th anniversary of the proclamation of the Roman Catholic dogma of the Immaculate Conception.

Between July 1971 and February 1972, La Presse endured a seven-month labour dispute between its then-owner Power Corporation of Canada and 11 trade unions, prompted by the introduction of new printing technology that could have jeopardized the jobs of newspaper typographers.

[5] The graphic design was modernized, new sections were created, international coverage was greatly increased,[5] and many new young, up-and-coming journalists were hired.

These changes had a significant positive impact on quality and circulation, to the point that the paper is now considered a rival to Le Devoir for the title of Quebec's newspaper of record.

Similarly, with Stephen Harper's Conservatives having been in power for nine years at the time, La Presse endorsed Justin Trudeau's Liberal Party in the 2015 election.

Noted journalists associated with the paper include Patrick Lagacé, Yves Boisvert, Agnès Gruda and Lysiane Gagnon.