The band originated in Madrid with six members but the remaining four relocated to Mexico in 2001 after signing with Ariola and began recording their debut album Primera toma ("Take #1") which was released in 2002.

In the same year, they performed Voy a pasármelo bien ("I'm going to have a good time") in the tribute-album to Hombres G and Si yo fuera mujer ("If I were a woman") for the soundtrack of Dame tu cuerpo, a Mexican film starred by Rafael Sánchez Navarro and Luis María Zetina.

Their second single Algo Más ("Something More", written by Natalia) talks about a feeling the author says is not love but it is "something more" that fulfills her and it is stronger than "distance, pain and nostalgia".

The scene and wardrobe are set in the 1950s and the band is seen performing at a nightclub with a couple enjoying the song and afterwards inspired by its lyrics leave their seats to caress each other.

[3] In 2005, they received more than 1.5 million votes to become Grupo Latino del año ("Latin band of the year") on the music video network Ritmoson of Televisa.

After seven years, La Quinta Estación's guitarist, Pablo Domínguez, decided it was time for him to leave the group and joined to Varsovia.

[11] On February 20, 2010, Cadena Dial (a Spanish radio station) falsely announced the "exclusive" news of the final separation of La Quinta Estación, i.e. breaking the duo Angel and Natalia.