The stable was created when WWE aired vignettes of two arrogant "Frenchmen" (Sylvain Grenier and René Duprée, who are both actually French-Canadians) attacking the United States and its policy from a French news studio.

After several minutes of Grenier calling America barbarians and saying that France would not allow the US to be the police force of the world, the sound of glass shattering suddenly filled the arena when Steve Austin cleared the ring of La Résistance and said some unflattering remarks about the French nation.

On the May 26, 2003, edition of Raw, Grenier defeated Rob Van Dam in a Flag match to win a World Tag Team Championship shot.

At WrestleMania XX, La Résistance competed in a Fatal 4-Way match for the World Tag Team Championship where Booker T and Rob Van Dam retained the titles.

Several months after the loss of Duprée, La Résistance went on to defeat Edge and Chris Benoit for the World Tag Team Titles in Grenier's home town of Montreal, Quebec, to a standing ovation.

With the help of Raw General manager Eric Bischoff, La Résistance managed to keep hold of the titles for five months, but at the first interactive PPV Taboo Tuesday they had to defend their titles against the two Superstars who were not voted for by the fans to get a World Heavyweight Championship shot at Triple H. This stipulation meant they would either face the team of Edge and Benoit, Edge and Shawn Michaels, or Benoit and Michaels.

As Grenier and Conway invoked their rematch clause thirteen days later on Raw, the dissension between Benoit and Edge would continue and finally be their undoing as La Résistance won the titles back.

This time, La Résistance defeated Regal and Jonathan Coachman, who was taking the place of the legitimately injured Eugene (who would miss several months due to a left patella tear at New Year's Revolution).

During their "last shot" for the gold the team thought they had won back the titles only to have the decision reversed by referee Mike Chioda due to La Résistance's Grenier pinning Tajiri, not Regal, who was the legal man.

[5] On November 5, 2016, Grenier and Duprée reunited to defeat Michael Von Payton and Platinum Preston Perry at Great North Wrestling: Star Stampede in Hawkesbury, ON.

[7] On August 12, 2017, Grenier and Duprée defeated Kryss Thorn and Scotty O'Shea to win the Canadian Wrestling Federation Tag Team Championship.