Prior to the CPR's laying rails on or about September 5, 1882, the Roman Catholic Church purchased land to establish the St. Hyacinthe Seminary.

This land was on the north shore of the Riviere Sale (La Salle River).

The area was inhabited by English and Métis families who had lain claims to the lands.

The Roman Catholic Church purchased the land to establish the Parish of St.-Hyacinthe of La Salle.

However, as the land was broken, potholes developed due to the flat prairie not having enough drainage.

The La Salle Chamber of Commerce was founded in 1990 by concerned citizens in the area.

Today, La Salle is the largest urban centre in the RM of Macdonald.

With a population of approximately 1,589,[1] the community members are active in establishing facilities and infrastructure that will meet the needs of the urban centre.

With the La Salle River winding through the community, activities can be pursued on a year-round basis.