La Serena is a comarca located in the east of the province of Badajoz, Extremadura, Spain.

It is a comarca based on a natural region which includes plains, as well as some low ranges of the Sierra Morena.

The climate is continental, with strong fluctuations.

It grows fine grass grazed by merino sheep that produce a renowned wool and whose milk yields a well known cheese denominated La Serena cheese, which is a protected product by its origin.

This article about a location in the autonomous community of Extremadura, Spain is a stub.