The town is crossed by the road going from Pré-Saint-Didier in the north-west up to the Little St Bernard Pass in the south-east linking Italy to Bourg-Saint-Maurice and the Isère Valley in France.

La Thuile has been the venue for several major annual international winter conferences: "Les Rencontres de Physique de la Vallée d'Aoste" organized by Italy's National Institute for Nuclear Physics, and "Rencontres de Moriond" organized by the French National Institute of Nuclear and Particle Physics.

In February 2016 the slopes of La Thuile hosted, for the first time in history, three competitions (two downhill and one super G) valid for the FIS Alpine Ski World Cup female.

In 2020, the female worldcup was held on Saturday 29 February and Sunday 1 March 2020, respectively with the downhill and the super-G, but the latter was cancelled due to bad weather.

Public transportation includes regular buses connecting La Thuile to Pré-Saint-Didier, the latter has a railway station connected to the Italian railway network via Aosta.