The La Vérendrye Trail (French: Le chemin La Vérendrye) is a series of highways in the Canadian province of Manitoba commemorating the oldest waterway fur-trading route in the province.

[2] The La Vérendrye Trail generally follows the Red and Winnipeg River systems used by early fur-traders to travel through eastern Manitoba.

The vehicular route begins at Provincial Trunk Highway (PTH) 101 (Winnipeg's Perimeter Highway) and comprises the following roads:[3] Communities along the trail include Lockport, East Selkirk, Powerview-Pine Falls, St. Georges, Lac du Bonnet, and Seven Sisters Falls.

The easternmost part of the trail lies within Whiteshell Provincial Park.

[5] A monument in the Municipality of Pembina commemorates Sieur de La Vérendrye's further travels through south-central Manitoba.