It is an adaptation of the book La patrona de Pablo Escobar of José Guarnizo based on history from Griselda Blanco.

[2] Griselda has a second chance to live, but to save her son, who is sentenced to die in the electric chair, Griselda agrees to work with the American government and help end a dangerous drug cártel, whose leader is José Joaquín Guerra, alias "El Diablo".

[3] Griselda feels lost and desolate in love, until she meets her guardian angel, Ángel Escudero.

This time, the widow will have to choose between returning to wear the crown as "Queen of Cocaine" or secure the future of her new family.

[3] The series premiered on February 23, 2014, in United States on UniMás, on September 1, 2014, in Colombia on Caracol Televisión.