Laboratory Investigation is a peer-reviewed medical journal of pathology published by Elsevier.

It is the official journal of the United States and Canadian Academy of Pathology.

According to the Journal Citation Reports, Laboratory Investigation has a 2022 impact factor of 5.0, ranking it 14th out of 76 in the category Pathology.

[1] Laboratory Investigation offers prompt publication of high-quality original research that advances the understanding and classification of human disease.

Review articles must be of general interest to pathologists and contain original, in-depth analysis of the chosen topic.