Lacassine (French: La Cassine) is an unincorporated community and census-designated place (CDP) in Jefferson Davis Parish in the U.S. state of Louisiana.

[2] One story about the name of the community is that a tribe of Comanche Indians, led by their chief Lacassine, migrated to southwest Louisiana to hunt and fish in the early 19th century, settling near this place.

[citation needed] Another story about the name states that the part of the parish where the community is located was visited regularly by different tribes of the area, including the Atakapa and Choctaw people.

According to Monsignor Jules Daigle, noted authority of the Cajun language, it was named for a small house built by an Indian chief in that location.

[4] Lacassine is in western Jefferson Davis Parish along U.S. Route 90, which leads west 6 miles (10 km) to Iowa and east the same distance to Welsh.