Ladies' Choice was Jones's fifth album of duets in five years, beginning with My Very Special Guests (1979), Double Trouble with Johnny Paycheck (1980), Together Again with Tammy Wynette (1980), and A Taste of Yesterday's Wine with Merle Haggard (1982).

The singer had also scored a top ten duet with Ray Charles on "We Didn't See A Thing" in 1983, a single that also featured guitar solos from Chet Atkins.

For the most part, Ladies' Choice pairs the singer up with up and coming female vocalists, although the album is noteworthy for featuring Jones's only duet with fellow country icon Loretta Lynn.

Ironically, the most famous song on the album was not a duet; the opening track, "She's My Rock", written by Gene Dobbins and sung by George as a tribute to his wife Nancy, rose to number 2 on the country singles chart.

Chris Woodstra of AllMusic contends that "rarely does this album strike anything above average" and believes "more than likely this was a marketing decision to pair the old-school singer with the up-and-coming country ladies of the '80s.