Lady Bunny was born in Wilmington, North Carolina,[2] but grew up in Chattanooga, Tennessee, and describes her childhood as having been "wonderful and [she] lucked out in the parents department.

"[3] Her mother is a retired registered nurse and her father is a history professor at the University of Tennessee at Chattanooga.

[4] When Bunny was 11, her family moved to Ghana for a year to accommodate her father, who had received a Fulbright Scholarship.

"It was the best year of my life", she said, remembering banana trees in her backyard and a giant snake that slithered on the road.

During this period, she also held several odd jobs such as working in an ice cream parlor and in sales for publisher Ralph Ginzburg.

[4] Soon, Lady Bunny became one of the Club Kids[13] and in 1985, she organized the first Wigstock,[14] an annual drag queen festival that lasted until 2005, and was later revived in 2018.

[17] In response to the backlash, Pridelines issued an apology, rescinded Lady Bunny’s National Icon Award, and reaffirmed their support for Fantasia, emphasizing the gala’s intended focus on unity and community.

[18] Lady Bunny is known for her "big curves, bigger hair" and is one of the legendary and ubiquitous New York City drag queens that is still performing today.

Hideaway by Canadian musical Kiesza is a pop song Lady Bunny regularly spins during DJ sets for its popular and underrated appeal.

In 2005, she was a roaster on the Comedy Central roast of Pamela Anderson[27] and released her first DVD, Rated X for X-tra Retarded.

[28] Lady Bunny served on the judges' panel on the spinoff show RuPaul's Drag U, which aired on the Logo TV network from 2010 to 2012.

During the fifth season of RuPaul's Drag Race, contestant Alaska Thunderfuck 5000 impersonated Bunny for the Snatch Game.

[30] In 2003, Lady Bunny made a guest appearance in the Sex and the City episode "Boy, Interrupted", as the emcee at the LGBT prom.

[31] In 2021, Lady Bunny featured in NewsBeat, a news show written by Luke Evendon with executive producer Clay Aiken.