The lyrics include hyperbolic statements about the artist's lifestyle and his interactions with women.

"Lady Killers" is about a man who is confident, perhaps to the point of arrogance, in his ability to attract and seduce women.

Moore called it "a fun, feel-good track that showcases G-Eazy’s playful side".

Following resurgence in streaming due to its growing use on TikTok over ten years after its initial release, the song charted in the United Kingdom and other countries.

[7] HNHH of HotNewHipHop felt that it "strengthens G-Eazy's already impressive body of work, which has seen positive change over the years".