The Lafayette–New Iberia–Opelousas combined statistical area is made up of six parishes in the Acadiana region of southern Louisiana.

The region consists of seven parishes: Acadia, Iberia, Lafayette, St. Landry, St. Martin, and Vermilion Parishes.

[citation needed] As of the census[4] of 2010, there were 550,134 people, 188,219 households, and 134,322 families residing within the CSA.

The racial makeup of the CSA was 70.42% White, 27.07% African American, 0.25% Native American, 1.01% Asian, 0.02% Pacific Islander, 0.40% from other races, and 0.84% from two or more races.

Males had a median income of $31,564 versus $18,942 for females.