Laignes (French pronunciation: [lɛɲ]) is a commune in the Côte-d'Or department, in the Bourgogne-Franche-Comté region in eastern France.

Refined flints and tombs dating to the Iron Age attest to the antiquity of the site's occupation.

The crossing of the roads from Auxerre to Langres and Alise to Vertault made it a very active place for the Lingones during the Gallo-Roman period: an ancient potter's wheel was discovered near the train station bearing witness to the area's artisanal past.

To resist various assaults from armed bands that ravaged the country during the Hundred Years' War, the city surrounded itself with fortifications; of which only a single round tower remains.

On the eve of the French Revolution, Laignes depended on goods from the Bailiwick of Sens in the County of Champagne and spiritual guidance from the Deanery of Châtillon-sur-Seine, part of the Diocese of Langres.