LECOM has a Branch Campus in Bradenton, Florida[2] and additional locations in Greensburg, Pennsylvania, and Elmira, New York.

In the late 1980s, the growing need for new physicians, especially in the Erie area, was becoming increasingly evident and as a result the leaders of Millcreek Community Hospital in Millcreek Township, Pennsylvania founded the health system's now namesake, the Lake Erie College of Osteopathic Medicine, in December 1992.

[26] Furthermore, LECOM Health offers ACGME-accredited fellowships on child and adolescent psychiatry and sports medicine for eligible physicians.

LECOM and Creighton University offer the only two distance education pathways for the primary Pharma degree in the nation.

[citation needed] The School of Dental Medicine (SDM) prepares students for the practice of general dentistry.

The SDM operates full-service dental practice offices in Bradenton where third-year students treat patients under the supervision of licensed dentists.

[28] In 2002, the college expanded the main building with a three-story addition which included classroom, laboratory and office space for the School of Pharmacy.

The purchase allowed LORD Corporation to keep its Erie operations by moving to a new location just south of the city.

The original campus building, containing two large lecture halls and 24 smaller classrooms, houses the College of Osteopathic Medicine and the School of Pharmacy.

Classrooms, laboratories and offices are housed in two buildings on the Seton Hill University campus in Greensburg, Pennsylvania.

[30] LECOM has sent third- and fourth-year medical students to Arnot Health in Elmira and other nearby hospitals for clinical education since 2012.

Additionally, the LECOM's name was featured on the BayHawks' jerseys and court design at Erie Insurance Arena.