Lake Frome National Park, formerly Lake Frome Regional Reserve, is a protected area located in the Australian state of South Australia about 750 kilometres (470 miles) north-east of the state capital of Adelaide, in the Northern Flinders Ranges.

Lake Frome Regional Reserve was proclaimed as a Regional Reserve on 19 December 1991 for the following purposes and uses:[4][5]…to extend the conservation management of the adjoining Vulkathunha-Gammon Ranges National Park.

It conserves a large arid salt lake system that is of regional geological significance.

[2] As an ephemeral a salt lake system, it is representative of very rare and little-known environments, and therefore considered to be of national significance.

[6] Since 2013, it has been located within the boundaries of the gazetted locality of Lake Frome[8] The regional reserve was classified as an IUCN Category VI protected area.