Lake Manitou (French: Lac Manitou) is a lake located in the unorganized territory of Lac-Jérôme, in the Minganie Regional County Municipality, in the Côte-Nord, in the province of Quebec, Canada.

The Manitou River flows through the lake from north to south, and continues to the Gulf of Saint Lawrence.

It is in the center-south of the Manitou River basin and covers 41.7 square kilometres (16.1 sq mi).

The lake is almost 25 kilometres (16 mi) long but only 1–2 kilometres (0.62–1.24 mi) wide, formed by flooding an old trough-shaped glacial valley with steep sides that rise to over 500 metres (1,600 ft) in places.

[3] A map of the ecological regions of Quebec shows the lake is in sub-region 6j-S of the east spruce/moss subdomain.