Consumption of bass, crappies, carps, and catfish from the lake is dangerous, but blue gill and sucker fish may be eaten only once per week safely.

The California Office of Environmental Health Hazard Assessment (OEHHA) has developed a safe eating advisory for Lake Nacimiento, based on levels of mercury found in fish caught from this water body.

The lake can fill quickly in the winter from river surges resulting from downpours upstream in the Santa Lucia Range so the level is not usually allowed to capacity until May 1 of each year.

[5] In October 2007, construction started on a pipeline to bring water from the lake to Paso Robles, Templeton, Atascadero, and San Luis Obispo.

The Monterey County Parks Department's primary jurisdiction is the lake waters, up to the high-water mark and the resort area.

Overnight camping on the lake, outside of the resort, is not allowed; setting up or venturing on land above the high-water mark is considered trespassing.