Previous assignment and reason for departure denoted in parentheses Lancaster High School offers a wide variety of courses.

These courses include Calculus AB, Chemistry, Statistics, Biology, Music Theory, English Language, English Literature, US History, Spanish Language, U.S. Government & Politics, Macroeconomics, and Physics C. Averages that students receive for these classes are weighted +1.07% to compensate for the advanced level of subject material covered.

[5][independent source needed] Lancaster High School has a large and varied program of honors classes.

Honors courses include World History, English (multiple years), Chemistry, Earth Science, and Precalculus.

[5][independent source needed] Lancaster High School has a large selection of technology courses.

[5][independent source needed] The teachers in the Art Education Department are working artists themselves who have received local as well as national and international awards for their artwork in Drawing, Painting, Jewelry, Fibers and Ceramic.

Students also have the opportunity to take courses focusing on physics, astronomy, meteorology, anatomy, and oceanography.

Advanced Placement course offerings include United States history, American government, and macroeconomics.

[7] The Lancaster Marching Redskins were officially promoted to the "National Class" of the New York State Field Band Conference on February 20, 2014.

Recent musicals include Cinderella (2020), Legally Blonde (2019), Sister Act (2018), Mary Poppins (2017), Crazy for You (2016), and The Little Mermaid (2015).

The Lancaster Middle Schools participates in many spring events such as the Holland Tulip Festival and parade pageants in Springville and Batavia, New York.

The Lancaster Marching Band has performed all over the country, including the AutoZone Liberty Bowl in Memphis, Tennessee; Walt Disney World Main Street USA parades in Orlando, Florida; the Gator Bowl in Jacksonville, Florida; Jacksonville Jaguars and Buffalo Bills halftime shows;Band of America (BOA) performances in Indianapolis, Indiana; and at the Pearl Harbor Memorial Parade in Waikiki, Hawaii.

Students apply for five of the academies halfway through their freshman year, while the sixth (Project Lead the Way) has entry requirements based entirely on academic performance in eighth grade.

The Academy of Finance operates a satellite branch of Bank of Akron that is located at Lancaster High School.

Based on a leading internship program, the Academy of Finance received a $5000 award to continue promoting student excellence.

The performing arts portion of the academy focuses on career exploration in fields such as music education, dance, and theatre.

Students are required to be a member of a performing ensemble to remain in the academy, in addition to taking courses such as music theory.

This program allows students to take engineering courses that can allow them to earn college credit from the Rochester Institute of Technology.

[14] Lancaster High School has teams in many sports, including baseball, American football, soccer, tennis, swimming, and basketball.

Due to these actions, the Lancaster School Board decided to immediately make a decision regarding the district's mascot name.

[20] In reaction to this decision to change Redskin name, there were some protests, including one by students of the Lancaster School District.

About 10% of the student body of the Lancaster School District participated in a walkout in response of the name change on March 19, 2015.