It serves as a transfer point for several public transportation bus routes as well as the final Metrolink train station on the Antelope Valley Line that originates 69 miles (111 km) away in downtown Los Angeles, at Union Station.

Lancaster station is served by 22 Metrolink Antelope Valley Line trains (11 in each direction) each weekday.

Weekend service consists of 12 trains (6 in each direction) on both Saturday and Sunday.

Its plans to extend the line were expedited by almost 10 years following the 1994 Northridge earthquake, which collapsed sections of the SR 14 and I-5 freeways.

The Navy Seabee construction battalion and crews from the Los Angeles County Department of Public Works built an emergency Lancaster station in three days, and Metrolink service began on January 24,[3] one week after the earthquake.