Moore joined the New Orleans Saints in 2006 and played with them for eight seasons, and was a member of the 2009 Super Bowl championship team that beat the Indianapolis Colts.

As a receiver for the University of Toledo, Moore compiled 2,776 yards and 25 touchdowns on 222 receptions in 50 career games from 2001 to 2004.

[1] In the 2004 Mid-American Conference championship, he caught three of Bruce Gradkowski's four touchdown throws in a victory against Miami University.

He started alongside wide receiver Marques Colston and scored the first touchdown of his career on a 7-yard end around against the Seattle Seahawks with 05:18 remaining in the second quarter.

Against the Colts in Super Bowl XLIV, he had two receptions for 21 yards in the first half, and a 4th quarter acrobatic catch for a two-point conversion.

Due to Reggie Bush being sidelined with an injury, Moore had a breakout performance against the Atlanta Falcons in 2010.

Moore's role diminished in 2013 as he struggled with injuries, missing three games and recording only 457 yards and two touchdowns.

He became the team's fourth receiving option on the depth chart behind emerging rookie Kenny Stills.