He portrayed Cedric Daniels in The Wire (2002–2008), Phillip Broyles in Fringe (2008–2013), and Chief Irvin Irving in Bosch (2014–2020).

He also portrayed Detective Johnny Basil in the fourth season of Oz, Matthew Abaddon in Lost (2004–2010), Albert Wesker and his clones in the Netflix series Resident Evil (2022), and Zeus in Percy Jackson and the Olympians (2024), the latter of which was released posthumously and earned him a Children's and Family Emmy Award for Outstanding Supporting Performer nomination.

Reddick attended the Yale School of Drama in the early 1990s, receiving a Master of Fine Arts degree in 1994.

[7] Reddick was cast as Cedric Daniels in the HBO series The Wire, having also auditioned for the roles of Bubbles and Bunk Moreland.

[8][9] He joined ABC's series Lost in 2008,[10][11] where he played Matthew Abaddon, an employee of Charles Widmore, in multiple episodes.

Producers Damon Lindelof and Carlton Cuse considered Reddick for the role of Mr. Eko, but he was busy filming The Wire.

[16] In 2014, Reddick appeared as Charon in the action-thriller film John Wick, a role he reprised in its three sequels.

[a][2][36][37][35] Tributes were paid by colleagues and friends, including Reddick's The Wire co-stars Wendell Pierce and Isiah Whitlock Jr., as well as creator David Simon.

[41] Reddick's family asked fans to give to MOMCares, a Baltimore nonprofit supporting underserved mothers with babies in neonatal intensive care.

For the recipient, the award "symbolizes and celebrates not only a performer's talent, but their character; someone who's a true goodwill ambassador in the industry."

Show co-creator Rick Riordan remarked on working with Reddick, "He had a marvelous and quirky sense of humor.